Analysis of AD as a multistep process

 
   Lead Investigator:    Neil Cashman
   Institution      :    University of British Columbia
   E-Mail           :    neil.cashman@vch.ca
   Proposal ID      :    753



   Proposal Description:
   Using a multistep model applied to cancer epidemiology and ALS, we will           investigate the hypothesis that AD is a multistep process. The identification     of these steps would provide a framework for understanding AD pathogenesis. We    expect a strong linear relationship between the incidence rate and AD age of      onset in support of the multistep disease model. We will also determine how sex   and AD family history affects this linear relationship, and subsequently the      number of steps in AD.